
Molecular Disease Modeling Research Group
About the Group
The group's field of work and goals.
The Molecular Disease Modeling Research Group investigates cellular and molecular processes associated with disease using in vitro models and genetic analyses. Our research focuses on breast cancer biology, the biological effects of natural compounds, and molecular mechanisms that influence treatment response. By combining cell culture experiments with gene expression analyses and bioinformatics, we examine how polyphenols, propolis, and other bioactive substances affect cell proliferation, migration, oxidative stress, the cell cycle, and DNA repair.
Our work also encompasses genetic variation associated with disease susceptibility, dietary bioactive compounds, and the cellular compatibility of biomaterials. We aim to advance the understanding of disease mechanisms and experimentally evaluate potential molecular targets and biological effects for further investigation.
Team
The group's academic staff and graduate students.

Researchers
PhD and Master's Students
Research Topics
The scientific questions the group focuses on.
Breast Cancer Genetics
Stem Cell Biology
Nutrigenetics
In Vitro Disease Modeling Techniques
Projects
Ongoing and completed research projects.
In Vitro Investigation of the Anti-inflammatory and Antimicrobial Effects of Resveratrol on Cells Involved in Periodontal Inflammation
Investigation of the Cell Viability/Cytotoxicity and Biomineralization Properties of Proroot Material Used in Vital Pulp Therapy on Human Dental Pulp Stem Cells
Effects of Ellagic Acid and Cryptotanshinone on Triple-Negative Breast Cancer (TNBC) Cells
Publications
The group's work published in peer-reviewed journals.
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2026
Önal R., Dursun Saydam D., Terzi M., Seyhan M.F.
Gels 12(1): 53
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2026
Seyhan M.F., Eronat A.P., Diren A., Tuzuner M.B., Ceviz A.B., Yilmaz-Aydogan H., Ozturk T., Ozturk O.
Records of Natural Products 20(4): e25103658
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2026
Seyhan M.F., Timirci Kahraman Ö., Şenkal N., Kisakesen H.I., Eronat A.P., Öztürk T., Yanar F., Yılmaz Aydoğan H., Öztürk O.
Experimed 16(1): 51–60
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2026
Seyhan M.F., Dağdagül H., Eroğlu Ö.N., Okumuş İ.
International Journal of Secondary Metabolite 13(3): 726–734
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2025
Sokal-Dembowska A., Ergan K., Jarmakiewicz-Czaja S.
World Journal of Gastroenterology 31(40): 111375
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2025
Çintesun Ş., Karpuz M.M., Seyhan M.F., Maraklı S.
Chemistry Africa 8: 3815–3828
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2025
Yesil R., Aydogan C., Ozkara G., Tokat B., Yildiz A., Ebeoglu A.O., Seyhan M.F., Ozturk O., Yilmaz-Aydogan H.
Chronobiology International 42(9): 1161–1173
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2024
Seyhan M. F., Yılmaz Ü.
Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 11(4): 648–655
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2024
Evaluation of the genotoxicity, cytotoxicity, and bioactivity of calcium silicate-based cements
Esen M., Guven Y., Seyhan M.F., Ersev H., Tuna-Ince E.B.
BMC Oral Health 24(1): 119
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2024
Seyhan M.F., Timirci-Kahraman O., Eronat A.P., Yilmaz E., Ceviz A.B., Kisakesen H.I., Ozturk T., Yilmaz-Aydogan H., Ozturk O.
Records of Natural Products 18(2): 201–211
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2024
Cytotoxicity and Alkaline Phosphatase Activity of Curcumin, Aloin and MTA on Human Dental Pulp Cells
Dinç D., Seyhan M.F., Aktören O.
Indian Journal of Dental Research 35(2): 216–220
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2024
Bayralı Ülker E., Çetin Aktaş E., Seyhan M.F., İsbir T., Billur D., Timirci-Kahraman Ö.
Anticancer Research 44(12): 5351–5359
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2024
Çelik İ., Seyhan M.F., Ceviz A.B., Aydoğan Ç., Yılmaz Aydoğan H., Öztürk O.
İstanbul Journal of Pharmacy 54(1): 40–48
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2024
Yılmaz Ü., Seyhan M.F.
Experimed 14(1): 46–53
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2021
Tetraconazole-induced Programmed Cell Death in Schizosaccharomyces pombe
Ağuş H. H., Çetin A., Yalçın İ. N.
Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi 8(2): 833–843
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2021
Unal E., Aslan E.I., Ozturk T., Kurnaz Gomleksiz O., Kucukhuseyin O., Tuzuner M.B., Seyhan M.F., Ozturk O., Yilmaz Aydogan H.
Biochemical Genetics 59(6): 1413–1426
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2021
Eroglu Ozkan E., Seyhan M.F., Kurt Sirin O., Yilmaz-Ozden T., Ersoy E., Hatipoglu Cakmar S.D., Goren A.C., Yilmaz Aydogan H., Ozturk O.
Journal of Food Biochemistry 45(9): e13904
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2019
Seyhan M. F., Yılmaz E., Timirci-Kahraman Ö., Saygılı N., Kısakesen H. İ., Gazioğlu S., Gören A. C., Eronat A. P., Ceviz A. B., Öztürk T., Yılmaz-Aydoğan H., Öztürk O.
IUBMB Life 71(5): 619–631
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2017
Seyhan M. F., Yılmaz E., Timirci‐Kahraman Ö., Saygılı N., Kısakesen H. İ., Eronat A. P., Ceviz A. B., Bilgiç Gazioğlu S., Yılmaz‐Aydoğan H., Öztürk O.
IUBMB Life 69(9): 677-688
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2016
Tüzüner M. B., Öztürk T., Eronat A. P., Seyhan F., Kısakesen H. İ., Calay Z., İlvan Ş., Turna H., Yılmaz-Aydoğan H., Bermek H., Öztürk O.
Biochemical Genetics 54(6): 784-802
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2014
Kurt-Sirin O., Yilmaz-Aydogan H., Uyar M., Seyhan M.-F., Isbir T., Can A.
Gene 540(2): 226-231
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2013
Canbay E., Kahraman O. T., Bugra D., Caykara B., Seyhan M. F., Bulut T., Yamaner S., Ozturk O.
Expert Opinion on Therapeutic Targets 17(1): 1-6
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2013
Dağlar-Aday A., Toptaş B., Öztürk T., Seyhan F., Saygılı N., Eronat A. P., Akadam-Teker B., Yılmaz-Aydoğan H., Aksoy F., Öztürk O.
DNA and Cell Biology 32(1): 13-18
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2013
Increased Gastric Cancer Risk with PTEN IVS4 Polymorphism in a Turkish Population
Canbay E., Kahraman O. T., Bugra D., Caykara B., Seyhan M. F., Bulut T., Yamaner S., Ozturk O.
Genetic Testing and Molecular Biomarkers 17(3): 249-253
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2012
Kurt O., Yilmaz-Aydogan H., Uyar M., Isbir T., Seyhan M. F., Can A.
Molecular Biology Reports 39(6): 6723-6730
Conferences
National and international conference contributions.
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2025
SKBR3 Hücre Hattında Esansiyel Çay Ağacı Yağının Antikanser Etkinliğinin Belirlenmesi
Dağdagül H., Okumuş İ., Eroğlu Ö. N., Seyhan M. F.
26. Ulusal Biyoloji Kongresi
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2025
Seyhan M. F.
49th FEBS Congress
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2024
Balaban R. F., Acar T. Y., Seyhan M. F., Yılmaz Ü.
49. Ulusal Fizyoloji Kongresi
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2024
ALP Activity of Novel Pulp Therapy Agents on HDPC
Dinç D., Seyhan M. F., Aktören O.
FDI World Dental Congress / International Dental Journal
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2023
Evaluation of the genotoxicity, bioactivity and ALP activity of bioceramic based dental materials
Tuna İnce E. B., Esen M., Ersev H., Seyhan M. F.
29th International Association of Paediatric Dentistry / International Journal of Paediatric Dentistry
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2021
Cytotoxicity and ALP activity of MTA concentrations on human dental pulp stem cells
Dinç D., Seyhan M. F., Ali M., Aktören O.
28th Congress of the International Association of Paediatric Dentistry / International Journal of Paediatric Dentistry
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2019
Seyhan M. F., Eroğlu Özkan E., Kurt Şirin Ö.
7th Drug Chemistry Conference: Design, Synthesis, Production and Standardization of Drug Active Substances
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2019
Ünal Rıdvanov E., Aslan E. I., Kurnaz Gömleksiz Ö., Öztürk T., Tüzüner M. B., Seyhan M. F., et al.
7th International Congress of Molecular Medicine
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2019
Kurkumin, Aloin, MTA’nın İnsan Dental Pulpa Kök Hücrelerinde Sitotoksisitelerinin İncelenmesi
Dinç D., Seyhan M. F., Aktören O.
Türk Dişhekimleri Birliği 25. Uluslararası Dişhekimliği Kongresi




