Moleküler Hastalık Modelleme Araştırma Grubu

Grup Hakkında

Grubun çalışma alanı ve hedefleri.

Ekip

Grubun akademik kadrosu ve lisansüstü öğrencileri.

Baş Araştırmacı

Mehmet Fatih Seyhan

Dr. Öğr. Üyesi

mehmetfatih.seyhan@yeniyuzyil.edu.trORCIDORCID: 0000-0002-6218-0049

Araştırmacılar

Kübra Ergan

Arş. Gör.

kubra.ergan@yeniyuzyil.edu.trORCIDORCID: 0000-0003-2902-1748

Merve Terzi

Dr. Öğr. Üyesi

merve.terzi@yeniyuzyil.edu.trORCIDORCID: 0000-0003-3397-9692

Ahsen Çetin

Uzm.

ahsen.cetin@yeniyuzyil.edu.trORCIDORCID: 0000-0001-5341-3456

Doktora ve Yüksek Lisans Öğrencileri

HA

Hayat Arısüt

Yüksek lisans öğrencisi

Melisa Eren

Yüksek lisans öğrencisi

melisaaeeren@gmail.comORCIDORCID: 0009-0007-2624-829X

ZS

Zeynep Nur Sarıduman

Yüksek lisans öğrencisi

Araştırma Konuları

Grubun odaklandığı bilimsel sorular.

Projeler

Yürütülen ve tamamlanan araştırma projeleri.

Yayınlar

Grubun hakemli dergilerde yayımlanan çalışmaları.

• 2026

  Microencapsulation of Black Carrot Pomace Bioactive Compounds: Artificial Neural Network Modeling of Cytotoxicity on L929 Fibroblast Cells

  Önal R., Dursun Saydam D., Terzi M., Seyhan M.F.

  Gels 12(1): 53

  DOI
• 2026

  A mixture of potent polyphenolic anticarcinogens: Microarray analysis of their efficacy in MCF-7 and MCF-10A cell lines

  Seyhan M.F., Eronat A.P., Diren A., Tuzuner M.B., Ceviz A.B., Yilmaz-Aydogan H., Ozturk T., Ozturk O.

  Records of Natural Products 20(4): e25103658

  DOI
• 2026

  Transcriptomic Profiling Reveals Cell Cycle and DNA Repair Pathway Modulation in Triple-Negative Breast Cancer Cells Exposed to Polyphenol-rich Propolis

  Seyhan M.F., Timirci Kahraman Ö., Şenkal N., Kisakesen H.I., Eronat A.P., Öztürk T., Yanar F., Yılmaz Aydoğan H., Öztürk O.

  Experimed 16(1): 51–60

  DOI
• 2026

  Evaluation of the anti-carcinogenic effect of tea tree oil (Melaleuca alternifolia) on SK-BR-3 breast cancer cells

  Seyhan M.F., Dağdagül H., Eroğlu Ö.N., Okumuş İ.

  International Journal of Secondary Metabolite 13(3): 726–734

  DOI
• 2025

  Role of gut microbiota in the development of metabolic dysfunction-associated steatotic liver disease in inflammatory bowel disease

  Sokal-Dembowska A., Ergan K., Jarmakiewicz-Czaja S.

  World Journal of Gastroenterology 31(40): 111375

  DOI
• 2025

  Eco-Friendly Green Synthesis of Silver Nanoparticles Using Natural Mineral Resin Shilajit: Characterization and Evaluation of their Antifungal, Antibacterial, and Anticancer Activities

  Çintesun Ş., Karpuz M.M., Seyhan M.F., Maraklı S.

  Chemistry Africa 8: 3815–3828

  DOI
• 2025

  NR1D1 (REVERBalpha) may be novel candidate gene for coronary artery disease in men: Differential effects of NR1D1 polymorphisms by gender

  Yesil R., Aydogan C., Ozkara G., Tokat B., Yildiz A., Ebeoglu A.O., Seyhan M.F., Ozturk O., Yilmaz-Aydogan H.

  Chronobiology International 42(9): 1161–1173

  DOI
• 2024

  Evaluation of the Potential Cytotoxic, Antimetastatic, and Antioxidant Abilities of Chrysin and Astaxanthin in Triple-Negative Breast Cancer Cells

  Seyhan M. F., Yılmaz Ü.

  Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 11(4): 648–655

  DOI
• 2024

  Evaluation of the genotoxicity, cytotoxicity, and bioactivity of calcium silicate-based cements

  Esen M., Guven Y., Seyhan M.F., Ersev H., Tuna-Ince E.B.

  BMC Oral Health 24(1): 119

  DOI
• 2024

  Whole Genome Expression Analysis Identifies Multiple Targeted Integrative Effects of Polyphenol-Rich Propolis on HER-2-Positive Breast Cancer Cell Line

  Seyhan M.F., Timirci-Kahraman O., Eronat A.P., Yilmaz E., Ceviz A.B., Kisakesen H.I., Ozturk T., Yilmaz-Aydogan H., Ozturk O.

  Records of Natural Products 18(2): 201–211

  DOI
• 2024

  Cytotoxicity and Alkaline Phosphatase Activity of Curcumin, Aloin and MTA on Human Dental Pulp Cells

  Dinç D., Seyhan M.F., Aktören O.

  Indian Journal of Dental Research 35(2): 216–220

  DOI
• 2024

  Effects of Curcumin and Its Analogue Desmethoxycurcumin on miR-133b and Its Target Gene GSTP-1 in Cisplatin-resistant Ovarian Cancer Cells

  Bayralı Ülker E., Çetin Aktaş E., Seyhan M.F., İsbir T., Billur D., Timirci-Kahraman Ö.

  Anticancer Research 44(12): 5351–5359

  DOI
• 2024

  The therapeutic approach to fibrocystic breast disease in the MCF-10A cell culture model: Striking efficacy of polyphenols

  Çelik İ., Seyhan M.F., Ceviz A.B., Aydoğan Ç., Yılmaz Aydoğan H., Öztürk O.

  İstanbul Journal of Pharmacy 54(1): 40–48

  DOI
• 2024

  Effect of Ellagic Acid and Cryptotanshinone on Cell Viability/Cytotoxicity, Metastasis, and Oxidative Stress in Triple-Negative Breast Cancer Cells

  Yılmaz Ü., Seyhan M.F.

  Experimed 14(1): 46–53

  DOI
• 2021

  Tetraconazole-induced Programmed Cell Death in Schizosaccharomyces pombe

  Ağuş H. H., Çetin A., Yalçın İ. N.

  Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi 8(2): 833–843

  DOI
• 2021

  Peroxisome Proliferator-Activated Receptor Gamma Pro12Ala/C161T Genotypes and Risky Haplotype Altering Risk of Breast Cancer: A Turkish Case–Control Study

  Unal E., Aslan E.I., Ozturk T., Kurnaz Gomleksiz O., Kucukhuseyin O., Tuzuner M.B., Seyhan M.F., Ozturk O., Yilmaz Aydogan H.

  Biochemical Genetics 59(6): 1413–1426

  DOI
• 2021

  Antiproliferative effects of Turkish pomegranate (Punica granatum L.) extracts on MCF-7 human breast cancer cell lines with focus on antioxidant potential and bioactive compounds analyzed by LC-MS/MS

  Eroglu Ozkan E., Seyhan M.F., Kurt Sirin O., Yilmaz-Ozden T., Ersoy E., Hatipoglu Cakmar S.D., Goren A.C., Yilmaz Aydogan H., Ozturk O.

  Journal of Food Biochemistry 45(9): e13904

  DOI
• 2019

  Different propolis samples, phenolic content, and breast cancer cell lines: Variable cytotoxicity ranging from ineffective to potent

  Seyhan M. F., Yılmaz E., Timirci-Kahraman Ö., Saygılı N., Kısakesen H. İ., Gazioğlu S., Gören A. C., Eronat A. P., Ceviz A. B., Öztürk T., Yılmaz-Aydoğan H., Öztürk O.

  IUBMB Life 71(5): 619–631

  DOI
• 2017

  Anatolian honey is not only sweet but can also protect from breast cancer: Elixir for women from artemis to present

  Seyhan M. F., Yılmaz E., Timirci‐Kahraman Ö., Saygılı N., Kısakesen H. İ., Eronat A. P., Ceviz A. B., Bilgiç Gazioğlu S., Yılmaz‐Aydoğan H., Öztürk O.

  IUBMB Life 69(9): 677-688

  DOI
• 2016

  Evaluation of Local CYP17A1 and CYP19A1 Expression Levels as Prognostic Factors in Postmenopausal Invasive Ductal Breast Cancer Cases

  Tüzüner M. B., Öztürk T., Eronat A. P., Seyhan F., Kısakesen H. İ., Calay Z., İlvan Ş., Turna H., Yılmaz-Aydoğan H., Bermek H., Öztürk O.

  Biochemical Genetics 54(6): 784-802

  DOI
• 2014

  Combined effects of collagen type I alpha1 (COL1A1) Sp1 polymorphism and osteoporosis risk factors on bone mineral density in Turkish postmenopausal women

  Kurt-Sirin O., Yilmaz-Aydogan H., Uyar M., Seyhan M.-F., Isbir T., Can A.

  Gene 540(2): 226-231

  DOI
• 2013

  Investigation of BRAF V600E Mutation in Papillary Thyroid Carcinoma and Tumor-Surrounding Nontumoral Tissues

  Dağlar-Aday A., Toptaş B., Öztürk T., Seyhan F., Saygılı N., Eronat A. P., Akadam-Teker B., Yılmaz-Aydoğan H., Aksoy F., Öztürk O.

  DNA and Cell Biology 32(1): 13-18

  DOI
• 2013

  Increased Gastric Cancer Risk with PTEN IVS4 Polymorphism in a Turkish Population

  Canbay E., Kahraman O. T., Bugra D., Caykara B., Seyhan M. F., Bulut T., Yamaner S., Ozturk O.

  Genetic Testing and Molecular Biomarkers 17(3): 249-253

  DOI
• 2013

  Association betweenPTENIVS4 polymorphism and development of colorectal cancer in a Turkish population

  Canbay E., Kahraman O. T., Bugra D., Caykara B., Seyhan M. F., Bulut T., Yamaner S., Ozturk O.

  Expert Opinion on Therapeutic Targets 17(1): 1-6

  DOI
• 2012

  Evaluation of ERα and VDR gene polymorphisms in relation to bone mineral density in Turkish postmenopausal women

  Kurt O., Yilmaz-Aydogan H., Uyar M., Isbir T., Seyhan M. F., Can A.

  Molecular Biology Reports 39(6): 6723-6730

  DOI

Kongreler

Ulusal ve uluslararası kongre katılımları.

• 2025

  SKBR3 Hücre Hattında Esansiyel Çay Ağacı Yağının Antikanser Etkinliğinin Belirlenmesi

  Dağdagül H., Okumuş İ., Eroğlu Ö. N., Seyhan M. F.

  26. Ulusal Biyoloji Kongresi
• 2025

  Evaluation of Apigenin-Chrysin-Galangin Combination on MCF-7 and MCF-10A Cell Lines: A Potent Anti-Carcinogenic Agent

  Seyhan M. F.

  49th FEBS Congress

  Bağlantı
• 2024

  C-phycocyanin ve flavonoid kombinasyonlarının MDA-MB-231 hücrelerinde potansiyel antikarsinojenik özelliklerinin değerlendirilmesi

  Balaban R. F., Acar T. Y., Seyhan M. F., Yılmaz Ü.

  49. Ulusal Fizyoloji Kongresi
• 2024

  ALP Activity of Novel Pulp Therapy Agents on HDPC

  Dinç D., Seyhan M. F., Aktören O.

  FDI World Dental Congress / International Dental Journal

  DOI
• 2023

  Evaluation of the genotoxicity, bioactivity and ALP activity of bioceramic based dental materials

  Tuna İnce E. B., Esen M., Ersev H., Seyhan M. F.

  29th International Association of Paediatric Dentistry / International Journal of Paediatric Dentistry

  DOI
• 2021

  Cytotoxicity and ALP activity of MTA concentrations on human dental pulp stem cells

  Dinç D., Seyhan M. F., Ali M., Aktören O.

  28th Congress of the International Association of Paediatric Dentistry / International Journal of Paediatric Dentistry

  DOI
• 2019

  Phenolic Profile Characterization by LC-MS/MS Analysis And Antitumor Activities of Different Types of Pomegranate Extracts Cultivated in Turkey on MCF-7 and MCF-10A Cell Lines

  Seyhan M. F., Eroğlu Özkan E., Kurt Şirin Ö.

  7th Drug Chemistry Conference: Design, Synthesis, Production and Standardization of Drug Active Substances
• 2019

  Investigating the effects of peroxisome proliferator activated receptor gamma variations Pro12Ala and C161T on breast cancer

  Ünal Rıdvanov E., Aslan E. I., Kurnaz Gömleksiz Ö., Öztürk T., Tüzüner M. B., Seyhan M. F., et al.

  7th International Congress of Molecular Medicine
• 2019

  Kurkumin, Aloin, MTA’nın İnsan Dental Pulpa Kök Hücrelerinde Sitotoksisitelerinin İncelenmesi

  Dinç D., Seyhan M. F., Aktören O.

  Türk Dişhekimleri Birliği 25. Uluslararası Dişhekimliği Kongresi